Real-time detection of DNA interactions with long-period fiber-grating-based biosensor.

نویسندگان

  • Xianfeng Chen
  • Lin Zhang
  • Kaiming Zhou
  • Edward Davies
  • Kate Sugden
  • Ian Bennion
  • Marcus Hughes
  • Anna Hine
چکیده

Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability.

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عنوان ژورنال:
  • Optics letters

دوره 32 17  شماره 

صفحات  -

تاریخ انتشار 2007